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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-YAP-TEAD-MSC-4070
MSC-4070

Chemical Structure : MSC-4070

CAS No.: 3088065-01-1

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MSC-4070 (MSC4070)

货号: PC-25992Not For Human Use, Lab Use Only.

MSC-4070 is a selective, brain-penetrant TEAD1/2/4 inhibitor with IC50 of 14 nM in TEAD reporter assays in SK-HEP-1 cells, with selectivity for TEAD1, 2, 4 over TEAD3, has IC50 of 30 nM in NCI-H226 viability assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MSC-4070 is a selective, brain-penetrant TEAD1/2/4 inhibitor with IC50 of 14 nM in TEAD reporter assays in SK-HEP-1 cells, with selectivity for TEAD1, 2, 4 over TEAD3, has IC50 of 30 nM in NCI-H226 viability assays.

物理化学性质&存储条件

分子量 452.45
分子式 C22H24F4N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-ethyl-3-(5-fluoro-2-methyl-6-(((1r,4r)-4-(trifluoromethyl)cyclohexyl)oxy)pyrimidin-4-yl)-1-methyl-1,4-dihydro-5H-pyrrolo[3,2-b]pyridin-5-one

参考文献

1. Timo Heinrich, et al. RSC Med Chem. 2026 Jan 7. doi: 10.1039/d5md00928f.

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