MS7710

Chemical Structure : MS7710

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货号: PC-24389Not For Human Use, Lab Use Only.

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50 mg		Get quote
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250 mg		Get quote

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生物&药学活性

MS7710 is a brain-penetrant HCN channel inhibitor, exhibits potent inhibitory effect on VTA DA Ih currents as compared to Cilobradine, and greater inhibitory effect than Cilobradine on VTA DA firing rate.
MS7710 displays inhibitory effects on Ih currents and firing rate of VTA DA neurons.
MS7710 decreases firing rate and bursting activity in VTA DA neurons of male and female mice.
MS7710 reverses CSDS-induced hyperdopaminergia in male CSDS-susceptible mice.
MS7710 improves CSDS-induced social, reward, and cognitive deficits.

物理化学性质&存储条件

分子量	452.60
分子式	C27H36N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-7,8-dimethoxy-3-((1-(3-methoxyphenethyl)piperidin-3-yl)methyl)-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one

参考文献

1. Emily M Teichman, et al. Mol Psychiatry. 2025 Apr 8. doi: 10.1038/s41380-025-02972-8.

MS7710

生物&药学活性

物理化学性质&存储条件

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MS7710

生物&药学活性

物理化学性质&存储条件

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