MS6178

Chemical Structure : MS6178

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货号: PC-24384Not For Human Use, Lab Use Only.

MS6178 is a MS5105-based CFTR DUBTAC, significantly increases the CFTR mutant protein level, stabilizes CFTR in a concentration-dependent manner.

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生物&药学活性

MS6178 is a MS5105-based CFTR DUBTAC, significantly increases the CFTR mutant protein level, stabilizes CFTR in a concentration-dependent manner.
MS6178 effectively stabilizes CFTR in a concentration-, time-, OTUB1- and CFTR-dependent manner and is approximately 10-fold more effective than the EN523-based CFTR DUBTAC NJH-2-057.

物理化学性质&存储条件

分子量	898.04
分子式	C47H53F2N7O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)-N-(7-((2-(5-(4-(4-(dimethylamino)but-2-enoyl)-2-oxopiperazin-1-yl)thiophen-2-yl)ethyl)amino)-7-oxoheptyl)benzamide

参考文献

1. Jin J, et al. Angew Chem Int Ed Engl. 2024 Aug 16:e202415168.

MS6178

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物理化学性质&存储条件

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MS6178

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物理化学性质&存储条件

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