MS479 | BRD4 PROTAC | Probechem Biochemicals

Chemical Structure : MS479

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MS479 (MS-479)

货号: PC-28729Not For Human Use, Lab Use Only.

MS479 is a specific SPOP-recruiting BRD4 PROTAC degrader with DC50 of 6.2 uM, recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein, effectively reduces the protein level of BRD4 short isoform (BRD4 (S)) in a time-, concentration-, GLP-, SPOP-, and ubiquitin-proteasome system (UPS)-dependent manner.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MS479 is a specific SPOP-recruiting BRD4 PROTAC degrader with DC50 of 6.2 uM, recruits the E3 ligase SPOP by directly binding its substrate GLP as a bridge protein, effectively reduces the protein level of BRD4 short isoform (BRD4 (S)) in a time-, concentration-, GLP-, SPOP-, and ubiquitin-proteasome system (UPS)-dependent manner.

物理化学性质&存储条件

分子量	1092.89
分子式	C59H82ClN11O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(10-(2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4] triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)decyl)-4-(4-((6-methoxy-2-morpholino-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-yl)amino)piperidin-1-yl)butanamide

参考文献

1. Zhijie Deng, et al. J Med Chem. 2025 Apr 24;68(8):8634-8647.

MS479 (MS-479)

生物&药学活性

物理化学性质&存储条件

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MS479 (MS-479)

生物&药学活性

物理化学性质&存储条件

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