Chemical Structure : MS.001
CAS No.: 53619-67-3
货号: PC-38239Not For Human Use, Lab Use Only.
MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥2580 | In stock | |
| 5 mg | ¥3980 | In stock | |
| 10 mg | ¥5880 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MS.001 is a small molecule that inhibits both the chaperone binding and ubiquitin ligase activity of C-terminus of Hsc70 interacting protein (CHIP) at low micromolar concentrations (IC50=3.3 uM).
MS.001 also inhibits CHIP/chaperone interaction with IC50 of 3.8 uM.
MS.001 does not have activity against isolated U-box or tetratricopeptide (TPR) domains, but instead only inhibited full-length CHIP.
| 分子量 | 303.292 | |
| 分子式 | C13H9N3O4S | |
| 外观性状 | Solid | |
| 储存条件 |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-nitro-7-(p-tolylsulfinyl)benzo[c][1,2,5]oxadiazole |
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1. Kanack AJ, et al. Chembiochem. 2022 Mar 18;23(6):e202100633.
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