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MS-L6

Chemical Structure : MS-L6

CAS No.: 106936-74-7

MS-L6

货号: PC-22285Not For Human Use, Lab Use Only.

MS-L6 is a novel small molecule OXPHOS inhibitor, exerts dual mitochondrial effects: mitochondrial electron transport chain complexe ETC-I inhibition and uncoupling of OXPHOS.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MS-L6 is a novel small molecule OXPHOS inhibitor, exerts dual mitochondrial effects: mitochondrial electron transport chain complexe ETC-I inhibition and uncoupling of OXPHOS.
MS-L6 inhibits respiration of hepatocytes and cancer cells via ETC-I.
MS-L6 decreases ΔΨm in rat liver mitochondria and cancer cells.
MS-L6 exhibits mild cytotoxic effects on several cancer cell lines and remarkably inhibits tumor growth in preclinical mouse cancer models without toxicity.

物理化学性质&存储条件

分子量 386.58
分子式 C20H26N4S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

6-(((Z)-N'-phenylcarbamimidoyl)thio)hexyl (E)-N'-phenylcarbamimidothioate

参考文献

1. Al Assi A, et al. Cell Death Dis. 2024 May 2;15(5):311.

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