MS-1020 | JAK3 inhibitor | Probechem Biochemicals

Chemical Structure : MS-1020

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MS-1020 (MS1020)

货号: PC-22495Not For Human Use, Lab Use Only.

MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner.

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生物&药学活性

MS-1020 is a selective, ATP-competitive small molecule JAK3 inhibitor, directly blocks JAK3 catalytic activity, potently inhibits persistently-active STAT3 in a cell type-specific manner.
MS-1020 inhibits STAT signaling in cancer cells with constitutive JAK3 activity, reduces tyrosine phosphorylated STAT3 levels in a dose-dependent manner in L540 cells.
MS-1020 blocks STAT signaling induced by IL-2 in rat T-lymphocyte Nb2 cells.
MS-1020 selectively affects cell viability harboring constitutively-active JAK3, induces apoptosis by down-regulating the expression of anti-apoptotic genes.

物理化学性质&存储条件

分子量	346.39
分子式	C21H18N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-naphthalenecarboxamide

参考文献

1. Kim BH, et al. Br J Haematol. 2010 Jan;148(1):132-43.

MS-1020 (MS1020)

生物&药学活性

物理化学性质&存储条件

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MS-1020 (MS1020)

生物&药学活性

物理化学性质&存储条件

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