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首页-小分子抑制剂&激动剂-Autophagy-ULK-MRT68921
MRT68921

Chemical Structure : MRT68921

CAS No.: 1190379-70-4

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MRT68921 (MRT-68921, MRT 68921)

货号: PC-42020Not For Human Use, Lab Use Only.

MRT-68921 is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MRT68921 is a potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
MRT68921 inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK.
MRT68921 reduces phospho-ATG13 and blocks autophagy in cells.

物理化学性质&存储条件

分子量 434.5771
分子式 C25H34N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-

参考文献

1. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.

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