MRT-83 hydrochloride | Smoothened inhibitor | Probechem Biochemicals

Chemical Structure : MRT-83 hydrochloride

CAS No.: 1359944-60-7

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MRT-83 hydrochloride (MRT83)

货号: PC-62174Not For Human Use, Lab Use Only.

MRT-83 hydrochloride is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

MRT-83 hydrochloride is a potent Smoothened antagonist that blocks Hedgehog (Hh) signaling in various assays with IC50 of 10 nM.
MRT-83 hydrochloride inhibits Bodipy-cyclopamine binding to human and mouse Smo but does not modify Wnt signaling, blocks BC binding to HEK-hSmo cells with IC50 of 4.6 nM.
MRT-83 hydrochloride abrogates the agonist-induced trafficking of endogenous mouse or human Smo, efficiently antagonizes Hh signaling in vivo.

物理化学性质&存储条件

分子量	575.062
分子式	C31H31ClN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-[1,1'-biphenyl]-4-carboxamide hydrochloride

参考文献

1. Roudaut H, et al. Mol Pharmacol. 2011 Mar;79(3):453-60.

2. Solinas A, et al. J Med Chem. 2012 Feb 23;55(4):1559-71.

3. Lauressergues E, et al. Pharmacol Res Perspect. 2016 Mar 4;4(2):e00214.

MRT-83 hydrochloride (MRT83)

生物&药学活性

物理化学性质&存储条件

参考文献

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MRT-83 hydrochloride (MRT83)

生物&药学活性

物理化学性质&存储条件

参考文献

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