MRT-31619 | CRBN degrader | Probechem Biochemicals

Chemical Structure : MRT-31619

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MRT-31619 (MRT31619)

货号: PC-25736Not For Human Use, Lab Use Only.

MRT-31619 is a potent, and selective, CRBN-dependent molecular glue degrader (MGD) of Cereblon (CRBN) with Ki of 7.72 nM and IC50 of 14.1 nM, drives CRBN homo-dimerization and degradation.

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生物&药学活性

MRT-31619 is a potent, and selective, CRBN-dependent molecular glue degrader (MGD) of Cereblon (CRBN) with Ki of 7.72 nM and IC50 of 14.1 nM, drives CRBN homo-dimerization and degradation.
MRT-31619 outperforms the CRBN homo-PROTAC in terms of potency, selectivity and speed.
MRT-31619 exhibits an excellent selectivity profile at 1-10 uM, including several known CRBN neosubstrates are degraded by the CRBN homo-PROTAC (ZFP91, ZNF692, ZNF653, RNF166, IKZF1).
MRT-31619 binds CRBN with IC50 of 14 nM in biochemical thalidomide CRBN displacement assays and promotes its degradation by ubiquitin-proteasome system (UPS).

物理化学性质&存储条件

分子量	486.57
分子式	C28H30N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-(8-benzoyl-2,8-diazaspiro[4.5]decan-2-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

参考文献

1. Langousis G, et al. Nat Commun. 2025 Nov 19;16(1):10157.

MRT-31619 (MRT31619)

生物&药学活性

物理化学性质&存储条件

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MRT-31619 (MRT31619)

生物&药学活性

物理化学性质&存储条件

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