MPL-5821 | p38α inhibitor | Probechem Biochemicals

Chemical Structure : MPL-5821

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MPL-5821 (MPL5821)

货号: PC-24996Not For Human Use, Lab Use Only.

MPL-5821 is a potent and myeloid selective p38α MAPK inhibitor, could be hydrolysied by hCE-1 to active form MPL-5822.

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生物&药学活性

MPL-5821 is a potent and myeloid selective p38α MAPK inhibitor, could be hydrolysied by hCE-1 to active form MPL-5822.
MPL-5821 not only inhibits IL-10 but also enhances LPS stimulated IL-12p70 and in contrast to conventional p38 MAPK inhibitors.
MPL-5821 potently inhibited the R848 induced IL-10 production, whilst sparing T-cell functionality.

物理化学性质&存储条件

分子量	533.52
分子式	C27H27F4N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl (4-(6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl)-3,5-difluorophenethyl)-L-alaninate

参考文献

1. Lund A, et al. Mol Immunol. 2025 Jul;183:145-155.

2. David Moffat, et al. Cancer Res (2018) 78 (13_Supplement): 3877.

3. Charlton, Michael H, et al. MedChemComm (2012), 3(9), 1070-1076.

MPL-5821 (MPL5821)

生物&药学活性

物理化学性质&存储条件

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MPL-5821 (MPL5821)

生物&药学活性

物理化学性质&存储条件

参考文献

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