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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Syk-MNS
MNS

Chemical Structure : MNS

CAS No.: 1485-00-3

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MNS (NSC 170724, 3,4-Methylenedioxy-β-nitrostyrene)

货号: PC-45992Not For Human Use, Lab Use Only.

MNS is a potent, selective Src and Syk kinase inhibitor with IC50 of 29.3 uM and 2.5 uM, respectively.

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500 mg ￥980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MNS is a potent, selective Src and Syk kinase inhibitor with IC50 of 29.3 uM and 2.5 uM, respectively.
MNS shows weak inhibitory effect on FAK and JAK2.
MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation.
MNS also is a potent inhibitor for ATP-induced NLRP3 inflammasome activation, inhibits IL-1β secretion in LPS-primed mouse macrophages with IC50 of 2 uM.

物理化学性质&存储条件

分子量 193.1562
分子式 C9H7NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,3-Benzodioxole, 5-(2-nitroethenyl)-

参考文献

1. Wang WY, et al. Mol Pharmacol. 2006 Oct;70(4):1380-9.

2. He Y, et al. J Biol Chem. 2014 Jan 10;289(2):1142-50.

3. Wang WY, et al. Biochem Pharmacol. 2007 Aug 15;74(4):601-11.

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