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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-MMV688845
MMV688845

Chemical Structure : MMV688845

CAS No.: 2208962-35-8

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MMV688845 ((R)-GSK1729177A)

货号: PC-26172Not For Human Use, Lab Use Only.

MMV688845 ((R)-GSK1729177A) is a small molecule inhibitor of M. abscessus complex with MIC90 of 5-10 uM for various M. abscessus strains in vitro, targets the RpoB subunit of RNA polymerase, also shows anti-M. tuberculosis.

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25 mg ￥2680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MMV688845 ((R)-GSK1729177A) is a small molecule inhibitor of M. abscessus complex with MIC90 of 5-10 uM for various M. abscessus strains in vitro, targets the RpoB subunit of RNA polymerase, also shows anti-M. tuberculosis.
MMV688845 is active against intracellular M. abscessus with an MIC90 of 16 uM.
MMV688845 induces significant reduction of colony forming units of M. abscessus strain ATCC 19977 with MBC90 of 15 uM. MMV688845 exhibits bactericidal activity in a macrophage infection model.

物理化学性质&存储条件

分子量 435.54
分子式 C24H25N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-(1-((2-Morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide

参考文献

1. Mann L, et al. Amino Acids. 2021 Aug;53(8):1187-1196.

2. Jeong J, et al. PLoS One. 2018 Apr 26;13(4):e0195595.

3. Mann L, et al. Microbiol Spectr. 2022 Dec 21;10(6):e0276022.

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