MMV665917 | Cryptosporidium parvum inhibitor | Probechem Biochemicals

Chemical Structure : MMV665917

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MMV665917 (MMV-665917)

货号: PC-26851Not For Human Use, Lab Use Only.

MMV665917 is an orally active piperazine-based compound with high selectivity for the blood stages of malaria parasites and for Cryptosporidium species (Cryptosporidium parvum, EC90=15 uM).

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生物&药学活性

MMV665917 is an orally active piperazine-based compound with high selectivity for the blood stages of malaria parasites and for Cryptosporidium species (Cryptosporidium parvum, EC90=15 uM).
MMV665917 shows roughly equivalent potency for multiple C. parvum lab and field isolates, and for the C. hominis TU502 isolate.
MMV665917 reduces parasite shedding to below detectable limits in a highly immunocompromised mouse model of chronic C. parvum infection.

物理化学性质&存储条件

分子量	357.80
分子式	C16H16ClN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperazinecarboxamide, N-(4-chlorophenyl)-4-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)-

参考文献

1. Stebbins E, et al. PLoS Negl Trop Dis. 2018 Jan 8;12(1):e0006183.

2. Jumani RS, et al. Antimicrob Agents Chemother. 2018 Mar 27;62(4):e01505-17.

3. Oboh E, et al. J Med Chem. 2021 Aug 12;64(15):11729-11745.

4. Lee S, et al. J Infect Dis. 2019 Jun 19;220(2):285-293.

MMV665917 (MMV-665917)

生物&药学活性

物理化学性质&存储条件

参考文献

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MMV665917 (MMV-665917)

生物&药学活性

物理化学性质&存储条件

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