MMV1581361

Chemical Structure : MMV1581361

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货号: PC-26055Not For Human Use, Lab Use Only.

MMV1581361 is a potent inhibitor of Plasmodium falciparum ATP4 (PfATP4), inhibits 3D7 P. falciparum Strain with IC50 of 0.03 uM, disrupts Na+ ion homeostasis in P. falciparum.

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生物&药学活性

MMV1581361 is a potent inhibitor of Plasmodium falciparum ATP4 (PfATP4), inhibits 3D7 P. falciparum Strain with IC50 of 0.03 uM, disrupts Na+ ion homeostasis in P. falciparum.
MMV1581361 shows high potency against 56 fresh Plasmodium falciparum field parasites collected from patients in the Tororo District, Uganda, with mean IC50 of 41 nM.
MMV1581361 (25 mg/kg) displays a moderate rate-of-kill profile similar to pyrimethamine in vitro and efficacy in the humanized P. falciparum Pf3D70087/N9 NODscidIL2Rγnull mouse model.
MMV1581361 demonstrates significant transmission-blocking potential, achieving 90% inhibition of male gamete exflagellation, a 98% reduction in mean oocyst intensity, and an 88% block in transmission

物理化学性质&存储条件

分子量	434.45
分子式	C16H17F3N4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Methyl-4-((4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)sulfonyl)thiophene-2-carboxamide

参考文献

1. Onyame HA, et al. J Med Chem. 2026 Feb 11. doi: 10.1021/acs.jmedchem.5c01954.

MMV1581361

生物&药学活性

物理化学性质&存储条件

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MMV1581361

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物理化学性质&存储条件

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