MM927

Chemical Structure : MM927

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货号: PC-25300Not For Human Use, Lab Use Only.

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生物&药学活性

NVL inhibitor MM927 is a bioavailable analog of MM17 and potent inhibitor of 60S ribosomal subunit assembly factor NVL with IC50 of 51 nM in cells expressing ectopic human NVL, inhibits HCT116 growth in a dose-dependent manner with IC50 of 53 nM.
MM927 also inhibits mouse NVL with an IC50 of 0.207 µM。
MM927 is a structurally related compound with improved metabolic stability compared with MM17.
MM927 reduces viability through the same mechanism as MM17, by blocking 60S biogenesis via NVL inhibition.
MM927 induces half-mer polysomes in polysome profiles and arrests 60S ribosome biogenesis in the nucleolus.
MM927 also triggers cell cycle arrest at both the G1/S and G2/M transitions, mirroring the effects of MM17, with G1/S arrest partially and G2/M arrest fully dependent on p53.
MM927 (35 mg/kg, i.p.) inhibits colorectal and leukemia tumor xenograft growth in vivo without overt toxicity.
MM927 inhibit ribosome biogenesis without causing DNA damage.

物理化学性质&存储条件

分子量	487.51
分子式	C26H18FN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(10-(but-2-yn-1-yl)-3-fluoro-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepin-7-yl)-3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxamide

参考文献

1. Guo HH, et al. bioRxiv [Preprint]. 2025 Aug 1:2025.07.31.667081.

MM927

生物&药学活性

物理化学性质&存储条件

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MM927

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