MM-129 | BTK/PD-L1 inhibitor | Probechem Biochemicals

Chemical Structure : MM-129

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MM-129 (MM129)

货号: PC-26319Not For Human Use, Lab Use Only.

MM-129 (MM129) is a novel inhibitor targeting BTK/PI3K/AKT/mTOR and PD-L1, inhibits intracellular pathways promoting tumorigenesis with a simultaneous reduction of PD-L1 expression.

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生物&药学活性

MM-129 (MM129) is a novel inhibitor targeting BTK/PI3K/AKT/mTOR and PD-L1, inhibits intracellular pathways promoting tumorigenesis with a simultaneous reduction of PD-L1 expression.
MM-129 significantly reduced tumor growth in mice challenged with DLD-1 and HT-29 cells.
MM-129 induces apoptosis through phosphatidylserine externalisation and loss of mitochondrial membrane potential.
MM-129 effectively inhibits tumour development in zebrafish embryo xenograft model, shows a markedly synergistic anticancer effect when used in combination with 5-FU.
MM-129 possesses antitumor activity in xenograft mouse models of colon cancer.

物理化学性质&存储条件

分子量	459.44
分子式	C17H17N9O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Proline, 4-hydroxy-1-[[4-(8-methyl-6H-pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazin-6-yl)phenyl]sulfonyl]-, methyl ester

参考文献

1. Hermanowicz JM, et al. Pharmaceutics. 2021 Aug 7;13(8):1222.

2. Hermanowicz JM, et al. Cancers (Basel). 2021 Jun 26;13(13):3203.

3. Hermanowicz JM, et al. J Enzyme Inhib Med Chem. 2021 Dec;36(1):535-548.

MM-129 (MM129)

生物&药学活性

物理化学性质&存储条件

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MM-129 (MM129)

生物&药学活性

物理化学性质&存储条件

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