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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-MLS 0038949
MLS 0038949

Chemical Structure : MLS 0038949

CAS No.: 496014-13-2

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MLS 0038949 (MLS0038949)

货号: PC-62545Not For Human Use, Lab Use Only.

MLS 0038949 is a potent, selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 uM, shows no activity against IAP and PLAP (IC50>100 uM).

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2 mg ￥2780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MLS 0038949 is a potent, selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 uM, shows no activity against IAP and PLAP (IC50>100 uM).
MLS 0038949 suppresses vascular smooth muscle cell calcification combined with PHOSPHO1 inhibitor MLS-0263839.
MLS 0038949 eliminates AMP hydrolysis in DRG and spinal lamina II of dKO mice.

物理化学性质&存储条件

分子量 344.385
分子式 C17H16N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide

参考文献

1. Street SE, et al. J Neurosci. 2013 Jul 3;33(27):11314-22.

2. Kiffer-Moreira T, et al. J Bone Miner Res. 2013 Jan;28(1):81-91.

3. Dahl R, et al. J Med Chem. 2009 Nov 12;52(21):6919-25.

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