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首页-小分子抑制剂&激动剂-Others-Small GTPase-MLS000532223
MLS000532223

Chemical Structure : MLS000532223

CAS No.: 16616-39-0

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MLS000532223 (MLS-000532223)

货号: PC-61468Not For Human Use, Lab Use Only.

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 of 16-120 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 of 16-120 uM.
MLS000532223 prevents GTP binding to several GTPases in a dose-dependent manner and is active in biochemical and cell-based secondary assays.
MLS000532223 inhibits actin rearrangements and changes in cell morphology, inhibits IgE induced morphological changes in mast cells; inhibits ligand-stimulated β-hexosaminidase secretion of RBL cells.

物理化学性质&存储条件

分子量 251.241
分子式 C15H9NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one

参考文献

1. Surviladze Z, et al. J Biomol Screen. 2010 Jan;15(1):10-20.

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