ML308 | KCNK9 inhibitor | Probechem Biochemicals

Chemical Structure : ML308

CAS No.: 1212238-62-4

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ML308 (ML-308)

货号: PC-20702Not For Human Use, Lab Use Only.

ML308 (ML-308) is a potent, selective inhibitor of two-pore domain potassium channel KCNK9 (TASK-3, K2P9.1) with IC50 of 130 nM in thallium influx fluorescent assays and 413 nM in automated electrophysiology assays, respectively.

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10 mg	￥4280	In stock
25 mg	￥7580	In stock
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生物&药学活性

ML308 (ML-308) is a potent, selective inhibitor of two-pore domain potassium channel KCNK9 (TASK-3, K2P9.1) with IC50 of 130 nM in thallium influx fluorescent assays and 413 nM in automated electrophysiology assays, respectively.
ML308 displays >50-fold selectivity over the closely-related, two-pore domain potassium channel, KCNK3, in fluorescent assays and displays little or no activity at 10 μM for Kir2.1, KCNQ2, and human ether-a go-go-related gene (HERG).
ML308 is a useful pharmacological probe for in vitro studies of KCNK9 function.

物理化学性质&存储条件

分子量	289.40
分子式	C15H19N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1-(Bicyclo[2.2.1]heptan-2-yl)ethyl)-5-(furan-2-yl)-4H-1,2,4-triazole-3-thiol

参考文献

1. Miller MR, et al. National Center for Biotechnology Information (US); 2010.

ML308 (ML-308)

生物&药学活性

物理化学性质&存储条件

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ML308 (ML-308)

生物&药学活性

物理化学性质&存储条件

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