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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-STAT-ML115
ML115

Chemical Structure : ML115

CAS No.: 912798-42-6

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ML115 (ML-115, CID-619100)

货号: PC-62732Not For Human Use, Lab Use Only.

ML115 is a potent, selective STAT3 agonist with EC50 of 2.0 nM, inactive against the related STAT1, STAT5 and NF-κB anti-targets.

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5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML115 is a potent, selective STAT3 agonist with EC50 of 2.0 nM, inactive against the related STAT1, STAT5 and NF-κB anti-targets.
ML115 increases the expression of BCL3, a known STAT3-dependent oncogene.
ML115 counteracts the effects of Ginsenoside Rc on cell viability and inflammatory responses in LPS-stimulated H9c2 and RAW264.7 cells.

物理化学性质&存储条件

分子量 322.75
分子式 C15H15ClN2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-Chloro-2,5-dimethoxyphenyl)-5-cyclopropylisoxazole-3-carboxamide

参考文献

1. Madoux F, et al. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–.

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