ML-T531 (CFK332-B) | hERG activator | Probechem Biochemicals

Chemical Structure : ML-T531

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ML-T531 (CFK 332-B, ML-T 531. CFK332-B)

货号: PC-60835Not For Human Use, Lab Use Only.

ML-T531 (CFK332-B) is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM.

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生物&药学活性

ML-T531 (CFK332-B) is a potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM.
ML-T531 exhibits no potentiation for KCNQ1 and KCNE1, and no noticeable effects on other cardiac channels including Cav1.2, Kir2.1, Nav1.5, and Kv4.3.
ML-T531 significantly potentiates hERG steady-state currents and tail currents in CHO cells at 10 uM, enhances voltage-dependent potassium current amplitudes in the presence of an Iks-specific inhibitor chromanol 293B.
ML-T531 potentiates native potassium currents in iPSC-derived cardiomyocytes, shortens the APD90 of LQT1 cardiomyocytes with EC50 of 5.71 uM, normalizes the disease phenotype of cardiomycytes derived from a patient with LQT1.

物理化学性质&存储条件

分子量	332.359
分子式	C20H16N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-benzoylphenoxy)-N-(pyridin-3-yl)acetamide

参考文献

1. Zhang H, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11866-71.

2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9.

3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439.

ML-T531 (CFK 332-B, ML-T 531. CFK332-B)

生物&药学活性

物理化学性质&存储条件

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ML-T531 (CFK 332-B, ML-T 531. CFK332-B)

生物&药学活性

物理化学性质&存储条件

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