ML-SI3 | TRPML inhibitor | Probechem Biochemicals

Chemical Structure : ML-SI3

CAS No.: 891016-02-7

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ML-SI3 (Mucolipin-specific synthetic inhibitor 3)

货号: PC-73173Not For Human Use, Lab Use Only.

ML-SI3 is a synthetic inhibitor of TRPML calcium channel blocker with IC50 of 4.7 μM and 1.7 μM for TRPML1/2 channel respectively.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
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100 mg		Get quote

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生物&药学活性

ML-SI3 is a synthetic inhibitor of TRPML calcium channel blocker with IC50 of 4.7 μM and 1.7 μM for TRPML1/2 channel respectively.
ML-SI3 blocks CCCP- and H2O2-induced autophagosome formation, suppresses CCCP-induced LC3-PARKIN co-localization (mitophagy).
(-)-isomer ML-SI3 is a potent inhibitor of TRPML1 and TRPML2 (IC50 values 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3.
The (+)-enantiomer ML-SI3 is an inhibitor on TRPML1 (IC50 5.9 μM), but an activator on TRPML 2 and 3.

物理化学性质&存储条件

分子量	429.579
分子式	C23H31N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide

参考文献

1. Li D, et al. Autophagy. 2021 Apr;17(4):872-887.

2. Leser C, et al. Eur J Med Chem. 2021 Jan 15;210:112966.

3. Xiaoli Zhang, et al. Nat Commun. 2016 Jun 30;7:12109.

ML-SI3 (Mucolipin-specific synthetic inhibitor 3)

生物&药学活性

物理化学性质&存储条件

参考文献

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ML-SI3 (Mucolipin-specific synthetic inhibitor 3)

生物&药学活性

物理化学性质&存储条件

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