ML-007 | M1/M4 mAChR agonist | Probechem Biochemicals

Chemical Structure : ML-007

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ML-007 (ML007)

货号: PC-25834Not For Human Use, Lab Use Only.

ML-007 is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830 nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors.

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生物&药学活性

ML-007 is a potent brain-penetrant agonist at both M1 and M4 muscarinic receptors with EC50 of 120 and 830 nM for huamn M1 and M4 receptors, 340 and 1600 nM for rat M1 and M4 receptors.
ML-007 has demonstrated compelling efficacy across a range of preclinical models of psychosis in schizophrenia including amphetamine-induced hyperlocomotion, PCP-induced hyperlocomotion, and conditioned avoidance response.
ML-007 is approximately ten-fold more potent than the comparator xanomeline.

物理化学性质&存储条件

分子量	165.20
分子式	C8H11N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((1R,5R)-3-azabicyclo[3.1.0]hexan-1-yl)-3-methyl-1,2,4-oxadiazole

参考文献

1. Chatterjee S, et al. Neuropsychopharmacology. 2025 Oct 4. doi: 10.1038/s41386-025-02256-3.

ML-007 (ML007)

生物&药学活性

物理化学性质&存储条件

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ML-007 (ML007)

生物&药学活性

物理化学性质&存储条件

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