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首页-小分子抑制剂&激动剂-Others-Other Targets-MKV3
MKV3

Chemical Structure : MKV3

CAS No.: 169120-56-3

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MKV3

货号: PC-26087Not For Human Use, Lab Use Only.

MKV3 is a specific, first-in-class, broad spectrum inhibitor of Cu-transporting P-type ATPases targeting P1B-type copper ATPases, binds within the Cu+ entry pocket, thereby blocking Cu+ delivery to the intramembranous transport site, dependently decreases Cu+-stimulated ATPase activity with IC50 of 130 nM for Escherichia coli Cu+-ATPase CopA (EcCopA).

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MKV3 is a specific, first-in-class, broad spectrum inhibitor of Cu-transporting P-type ATPases targeting P1B-type copper ATPases, binds within the Cu+ entry pocket, thereby blocking Cu+ delivery to the intramembranous transport site, dependently decreases Cu+-stimulated ATPase activity with IC50 of 130 nM for Escherichia coli Cu+-ATPase CopA (EcCopA).
MKV3 shows dose-dependent binding to GFP-tagged human ATP7B and ATP7A with MST Kd of 69.5 nM and 219 nM respectively.
MKV3 shows no measurable effect on Zn2+-stimulated EcZntA ATPase activity.
MKV3 specifically inhibits EcCopA-mediated ATP hydrolysis and Cu+ transport, consistent with a direct blockade of the Cu+ entry pathway.
MKV3 inhibits ATP7A-dependent copper transport in mammals and zebrafish.
MKV3 impairs ATP7A-mediated copper delivery to two cuproenzymes, lysyl oxidase and tyrosinase, which receive copper from ATP7A within the secretory pathway in wild-type B16-F10 cells.
MKV3 suppresses melanogenesis in metastatic lung tumors in mouse model of metastatic B16-F10 melanoma.
MKV3 is a broad-spectrum inhibitor of Cu+-ATPases across bacteria, protozoa, fungi, plants, and animals.

物理化学性质&存储条件

分子量 397.80
分子式 C17H11ClF3N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((2-chlorophenyl)amino)-2-cyano-3-thioxo-N-(3-(trifluoromethyl)phenyl)propanamide

参考文献

1. Shanbhag VC, et al. bioRxiv [Preprint]. 2026 Jan 24:2026.01.22.700703.

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