MKH066 | HER2 inhibitor | Probechem Biochemicals

Chemical Structure : MKH066

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MKH066 (MKH 066, MKH-066)

货号: PC-28439Not For Human Use, Lab Use Only.

MKH066 is a potent, selective HER2 tyrosine kinase inhibitor with IC50 of 2.5 nM against both EGFR and HER2.

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生物&药学活性

MKH066 is a potent, selective HER2 tyrosine kinase inhibitor with IC50 of 2.5 nM against both EGFR and HER2.
MKH066 shows substantial growth inhibition in BT-474 cells with IC50 of 0.273 ug/mL.
MKH066 induces accumulation in the G1/G0 phase and reduces populations in S and G2/M in HER2-overexpressing cells.
MKH066 significantly inhibits tumor growth and increased apoptosis in tumor tissues without noticeable systemic toxicity.

物理化学性质&存储条件

分子量	513.60
分子式	C32H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(4-((3-methyl-4-(quinolin-8-yloxy)phenyl)amino)quinazolin-6-yl)-3,6-dihydropyridin-1(2H)-yl)prop-2-en-1-one

参考文献

1. Koo J, et al. Drug Deliv Transl Res. 2026 Oct 1. doi: 10.1007/s13346-026-02220-8.

MKH066 (MKH 066, MKH-066)

生物&药学活性

物理化学性质&存储条件

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MKH066 (MKH 066, MKH-066)

生物&药学活性

物理化学性质&存储条件

参考文献

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