MKC-3946 |CAS:1093119-54-0 Probechem Biochemicals

Chemical Structure : MKC-3946

CAS No.: 1093119-54-0

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MKC-3946 (MKC3946;MKC 3946)

货号: PC-45675Not For Human Use, Lab Use Only.

MKC-3946 is a small-molecule IRE1α endoribonuclease domain inhibitor, blocks XBP1 mRNA splicing and triggers growth inhibition in MM cells.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MKC-3946 is a small-molecule IRE1α endoribonuclease domain inhibitor, blocks XBP1 mRNA splicing and triggers growth inhibition in MM cells.
MKC-3946 enhances cytotoxicity of ER stressors; in vivo active in mice model of ER stress.

物理化学性质&存储条件

分子量	380.4601
分子式	C21H20N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (3.8 mg/mL)
Chemical Name/SMILES	1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-

参考文献

1. Mimura N, et al. Blood. 2012 Jun 14;119(24):5772-81.

2. Zhang L, et al. BMC Cell Biol. 2014 Jul 10;15:29.

3. Sun H, et al. Oncotarget. 2016 Apr 5;7(14):18736-49.

MKC-3946 (MKC3946;MKC 3946)

生物&药学活性

物理化学性质&存储条件

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MKC-3946 (MKC3946;MKC 3946)

生物&药学活性

物理化学性质&存储条件

参考文献

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