MK-8153 | ROMK inhibitor | Probechem Biochemicals

Chemical Structure : MK-8153

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MK-8153 (MK8153)

货号: PC-24561Not For Human Use, Lab Use Only.

MK-8153 (MK8153) is a potent, selective inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) with IC50 of 5 nM, 3,400-fold over hERG.

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生物&药学活性

MK-8153 (MK8153) is a potent, selective inhibitor of renal outer medullary potassium channel (ROMK, Kir1.1) with IC50 of 5 nM, 3,400-fold over hERG.
MK-8153 inhibits current through rat ROMK, rKir1.1/HEK293 cells in electrophysiological recordings with an IC50 value of 2.5 nM.
MK-8153 also shows no activity against related inward rectifying potassium channels (Kir2.1, Kir4.1, and Kir7.1 IC50s > 100 μM) as well as the cardiac channels Nav 1.5 and Cav 1.2 (>30 μM).
MK-8153 (1-3 mg/kg/day) caused a dose-dependent decrease in systolic blood pressure in aged SHRs.

物理化学性质&存储条件

分子量	440.50
分子式	C24H28N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,8-Diazaspiro[4.5]decan-1-one, 2-(2,5-dihydro-4-methyl-5-oxo-3-furanyl)-8-[(2R)-2-(1,3-dihydro-4-methyl-1-oxo-5-isobenzofuranyl)-2-hydroxyethyl]-

参考文献

1. Jiang J, et al. J Med Chem. 2021 Jun 10;64(11):7691-7701.

MK-8153 (MK8153)

生物&药学活性

物理化学性质&存储条件

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MK-8153 (MK8153)

生物&药学活性

物理化学性质&存储条件

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