MK-4618 |CAS:1190389-15-1 Probechem Biochemicals

Chemical Structure : MK-4618

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MK-4618 (MK 4618;MK4618;Vibegron;KRP-114V;RVT-901)

货号: PC-60734Not For Human Use, Lab Use Only.

MK-4618 (Vibegron, KRP-114V, RVT-901) is a potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM.

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生物&药学活性

MK-4618 (Vibegron, KRP-114V, RVT-901) is a potent and selective full β3 adrenergic receptor agonist with EC50 of 1.1 nM.
MK-4618 (Vibegron) displays no activity for β1 and β2 receptors (EC50>20 uM).
MK-4618 (Vibegron) dose-dependently increases bladder capacity, decreased micturition pressure, and increased bladder compliance in rhesus monkeys, dose-dependently increases the circulating glycerol and fatty acid levels in rhesus and rat in vivo.
MK-4618 (Vibegron) shows the potential for treatment of overactive bladder with M2/M3 antimuscarinics.

物理化学性质&存储条件

分子量	444.535
分子式	C26H28N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(4-(((2S,5R)-5-((R)-hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxamide

参考文献

1. Edmondson SD, et al. J Med Chem. 2016 Jan 28;59(2):609-23.

2. Di Salvo J, et al. J Pharmacol Exp Ther. 2017 Feb;360(2):346-355.

MK-4618 (MK 4618;MK4618;Vibegron;KRP-114V;RVT-901)

生物&药学活性

物理化学性质&存储条件

参考文献

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MK-4618 (MK 4618;MK4618;Vibegron;KRP-114V;RVT-901)

生物&药学活性

物理化学性质&存储条件

参考文献

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