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首页-抗体和重组蛋白-Biosimilar Antibody-MK-4166
MK-4166

Chemical Structure : MK-4166

CAS No.:

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MK-4166 (Anti-human GITR mAb, human IgG1-Kappa; MK4166)

货号: PC-Ab1069Not For Human Use, Lab Use Only.

MK-4166 is a humanized IgG1 agonist monoclonal antibody targeting GITR. MK-4166 decreased induction and suppressive effects of T regs in vitro In human TIL cultures, MK-4166 induced phosphorylation of NFκB and increased expression of dual specificity phosphatase 6 (DUSP6), indicating that MK-4166 activated downstream NFκB and Erk signaling pathways..

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1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MK-4166 is a humanized IgG1 agonist monoclonal antibody targeting GITR. MK-4166 decreased induction and suppressive effects of T regs in vitro In human TIL cultures, MK-4166 induced phosphorylation of NFκB and increased expression of dual specificity phosphatase 6 (DUSP6), indicating that MK-4166 activated downstream NFκB and Erk signaling pathways.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Anti-Human GITR; human activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; human TNFRSF18; MK-4166

参考文献

1. 1, Mahne AE, et al. Cancer Res. 2017 Mar 1;77(5):1108-1118. 2, Sukumar S, et al. Cancer Res. 2017 Aug 15;77(16):4378-4388. 3, Papadopoulos KP, et al. Clin Cancer Res. 2021 Apr 1;27(7):1904-1911.

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