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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-MI-1061
MI-1061

Chemical Structure : MI-1061

CAS No.: 1410737-34-6

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MI-1061 (MI1061, MI 1061)

货号: PC-27558Not For Human Use, Lab Use Only.

MI-1061 is a potent and efficacious MDM2 inhibitor with binding IC50 of 4.4 nM and Ki of 0.16 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MI-1061 is a potent and efficacious MDM2 inhibitor with binding IC50 of 4.4 nM and Ki of 0.16 nM.
MI-1061 inhibits cell growth in the SJSA-1 and HCT-116 p53+/+ cell lines with IC50 of 100 and 250 nM respectively.
MI-1061 effectively induces robust cleavage of PARP in the tumor, indicative of strong apoptosis induction.
MI-1061 demonstrated strong antitumor activity and achieved significant tumor regression when administered orally daily for 14 days at 100 mg/kg in SJSA-1 xenograft model.

物理化学性质&存储条件

分子量 582.45
分子式 C30H26Cl2FN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)benzoic acid

参考文献

1. Aguilar A, et al. J Med Chem. 2014 Dec 26;57(24):10486-98.

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