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首页-小分子抑制剂&激动剂-Others-Other Targets-MG-257
MG-257

Chemical Structure : MG-257

CAS No.: 898562-94-2

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MG-257 (MG257)

货号: PC-25014Not For Human Use, Lab Use Only.

MG-257 is a small molecule ligand of galectin-3, impedes interaction between TREM2 and galectin-3 with IC50 of 91 nM in TR-FRET assays, attenuates TREM2 signaling.

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MG-257 is a small molecule ligand of galectin-3, impedes interaction between TREM2 and galectin-3 with IC50 of 91 nM in TR-FRET assays, attenuates TREM2 signaling.
MG-257 has dissociation constant (Kd) of 0.15 uM for galectin-3 using FA assay, SPR KD of 0.29 uM.
MG-257 can impede neuroinflammation triggered by Aβ aggregates and consequently would potentially be critical in enhancing Aβ clearance.
MG-257 reduced cytokine levels in the culture medium of BV2 cells coincubated with Αβ fibrils.

物理化学性质&存储条件

分子量 392.46
分子式 C25H20N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((4-(1-methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)quinoline

参考文献

1. Gabr M, et al. ACS Med Chem Lett. 2020 Aug 11;11(9):1759-1765.

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