METTL3 PROTAC KH12

Chemical Structure : METTL3 PROTAC KH12

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货号: PC-23104Not For Human Use, Lab Use Only.

KH12 is a potent METTL3 PROTAC degrader with DC50 of 220 nM in MOLM-13 cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

KH12 is a potent METTL3 PROTAC degrader with DC50 of 220 nM in MOLM-13 cells.
KH12 is capable of reversing differentiation and possesses anti-proliferative effects surpassing the small molecule inhibitors on MOLM-13 cells.
KH12 significantly suppresses the growth of various gastric cancer (GC) cells, where the m6A-independent activity of METTL3 plays a crucial role in tumorigenesis.

物理化学性质&存储条件

分子量	1054.36
分子式	C56H77F2N11O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-((S)-2-(8-((6-(4-(4-((4,4-dimethylpiperidin-1-yl)methyl)-2,5-difluorophenyl)-2-oxo-1,4,9-triazaspiro[5.5]undecan-9-yl)pyrimidin-4-yl)amino)octanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

参考文献

1. Hwang K, et al. Eur J Med Chem. 2024 Sep 6;279:116843.