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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-MELK-MELK inhibitor 17
MELK inhibitor 17

Chemical Structure : MELK inhibitor 17

CAS No.: 2095596-44-2

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MELK inhibitor 17

货号: PC-35237Not For Human Use, Lab Use Only.

MELK inhibitor 17 is a potent, selective MELK inhibitor with Ki/IC50 of 0.39/3 nM, >100-fold selectivity over CHK1, CAMKK2, NUAK1 and ERK2.

规格 价格 库存 数量
5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MELK inhibitor 17 is a potent, selective MELK inhibitor with Ki/IC50 of 0.39/3 nM, >100-fold selectivity over CHK1, CAMKK2, NUAK1 and ERK2.
MELK inhibitor 17 inhibits the expression of the anti-apoptotic protein Mcl-1 and proliferation of TNBC cells exhibiting selectivity for cells expressing high levels of MELK.

物理化学性质&存储条件

分子量 539.636
分子式 C31H33N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-5-carboxylate

参考文献

1. Edupuganti R, et al. Bioorg Med Chem. 2017 May 1;25(9):2609-2616.

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