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首页-小分子抑制剂&激动剂-Others-Other Targets-MDOLL-0286
MDOLL-0286

Chemical Structure : MDOLL-0286

CAS No.:

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MDOLL-0286 (MDOLL0286)

货号: PC-25528Not For Human Use, Lab Use Only.

MDOLL-0286 is a potent and selective inhibitor for ADP-ribosylhydrolase 3 (ARH3) with IC50 of 2.3 uM, selective against closely related homologues ARH1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MDOLL-0286 is a potent and selective inhibitor for ADP-ribosylhydrolase 3 (ARH3) with IC50 of 2.3 uM, selective against closely related homologues ARH1.
MDOLL-0286 inhibits ARH3's poly-ADP-ribose hydrolytic activity on cellular substrates.
MDOLL-0286 does not effectively inhibit the hydrolysis of mono-ADP-ribosylation from natural protein substrates.

物理化学性质&存储条件

分子量 299.38
分子式 C16H21N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-(2-(1-(4-(dimethylamino)phenyl)ethylidene)hydrazineyl)-5,6-dimethylpyrimidin-4(1H)-one

参考文献

1. Parviainen TAO, et al. ACS Chem Biol. 2025 Sep 15. doi: 10.1021/acschembio.5c00461.

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