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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-LIM Kinase (LIMK)-MDI-117740
MDI-117740

Chemical Structure : MDI-117740

CAS No.:

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MDI-117740 (MDI 117740)

货号: PC-25302Not For Human Use, Lab Use Only.

MDI-117740 is a highly potent, selective dual-LIMK1/2 inhibitor with binding Kd of 16/76 nM respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MDI-117740 is a highly potent, selective dual-LIMK1/2 inhibitor with binding Kd of 16/76 nM respectively.
MDI-117740 displays excellent cellular target engagement and potently inhibits p-cofilin levels in SH-SY5Y cells.
MDI-117740 does not bind PAK1–2/4, ROCK1/2, MRCKα or CAMK4, RIPK1.
MDI-117740 significantly inhibits wound closure compared to untreated control at 0.25 μM and 1 μM concentrations, has a more pronounced effect observed at 3 μM.
MDI-117740 exhibits potent inhibition of cofilin phosphorylation, and positive LIMK-dependent downstream phenotypic effects on cell migration.

物理化学性质&存储条件

分子量 400.48
分子式 C24H24N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-Benzyl-6-(cyclopropyl(phenyl)methyl)-7-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxamide

参考文献

1. Baldwin AG, et al. J Med Chem. 2025 Aug 6. doi: 10.1021/acs.jmedchem.5c00974.

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