MCB-22-174

Chemical Structure : MCB-22-174

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货号: PC-24407Not For Human Use, Lab Use Only.

MCB-22-174 is a novel small-molecule Piezo1 agonist with EC50 of 6.28 uM, effectively activates Piezo1 and initiates Ca2+ influx.

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生物&药学活性

MCB-22-174 is a novel small-molecule Piezo1 agonist with EC50 of 6.28 uM, effectively activates Piezo1 and initiates Ca2+ influx.
MCB-22-174 (5 uM) showed a significant rise of Runx2 mRNA level in mesenchymal stem cells (MSCs).
MCB-22-174 is a novel highly active agonist of Piezo1 could more effectively activate CaMKII/Erk signaling pathway than Yoda1 in vitro.
MCB‐22‐174 could significantly improve bone quality and MSC osteogenesis during HU in vivo.

物理化学性质&存储条件

分子量	429.36
分子式	C16H14DCl2N5OS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-1-((5-(5-(((2,6-dichlorophenyl)methyl-d)thio)-1,3,4-thiadiazol-2-yl)pyrazin-2-yl)amino)propan-2-ol

参考文献

1. Ruihan Hao, et al. Small Sci. 2024 Jun 30;4(9):2400061.

MCB-22-174

生物&药学活性

物理化学性质&存储条件

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MCB-22-174

生物&药学活性

物理化学性质&存储条件

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