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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-NADPH Oxidase (NOX)-MC4921
MC4921

Chemical Structure : MC4921

CAS No.:

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MC4921 (MC-4921)

货号: PC-28570Not For Human Use, Lab Use Only.

MC4921 (Compound 2a) is a potent, selective NADPH oxidase 2 (NOX2) inhibitor with IC50 of 1.4 uM (hNOX2).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MC4921 (Compound 2a) is a potent, selective NADPH oxidase 2 (NOX2) inhibitor with IC50 of 1.4 uM (hNOX2).
MC4921 effectively engages natively overexpressed NOX2 in PLB-985 cells with EC50 of 0.893 uM in CETSA assays.
MC4921 shows a competitive inhibition model with Ki of 0.991 uM for purified human NOX2.

物理化学性质&存储条件

分子量 578.72
分子式 C38H34N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

tert-Butyl 3-(bis(4-phenylquinolin-2-yl)amino)azetidine-1-carboxylate

参考文献

1. Chiara Lambona, et al. J Med Chem. 2026 Oct 22;69(20):24557-24585.

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