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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Influenza Virus-MBX2329
MBX2329

Chemical Structure : MBX2329

CAS No.: 1438272-42-4

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MBX2329 (MBX-2329)

货号: PC-20583Not For Human Use, Lab Use Only.

MBX2329 is a small molecule inhibitor of influenza virus via targeting influenza hemagglutinin (HA), specifically inhibits HA-mediated viral entry with potent antiviral activity against different influenza virus strains (IC50=0.3-5.9 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MBX2329 is a small molecule inhibitor of influenza virus via targeting influenza hemagglutinin (HA), specifically inhibits HA-mediated viral entry with potent antiviral activity against different influenza virus strains (IC50=0.3-5.9 uM).
MBX2329 binds to HA in a nonoverlapping manner, binds to the group 1 HA-specific conformational epitope in the HA stem region.
MBX2329 displays little inhibitory activity against HIV/LASV-GP, HIV/EBOV-GP, or HIV/VSV-G with IC50 values >100 uM.
MBX2329 inhibits influenza A H1N1 virus strains A/PR/8/34 (H1N1), A/Florida/21/2008 (H1N1-H275Y) (oseltamivir-resistant strain), A/Washington/10/2008 (H1N1), and A/California/10/2009 (H1N1) (2009 pandemic strain) with IC50s of 0.29 μM- 0.53 μM.
MBX2329 displays significantly less activity against influenza A H3N2 virus strain A/Texas/12/2007 (H3N2) and influenza B virus strain B/Florida/4/2006.
MBX2329 specifically inhibits influenza viruses of group 1 HA (H1 and H5 subtypes), but not group 2 HA (H3 and H7 subtypes).
MBX2329 exhibit strong synergy with oseltamivir.

物理化学性质&存储条件

分子量 283.84
分子式 C16H26ClNO
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-(2-ethylphenoxy)ethyl)azepane hydrochloride

参考文献

1. Basu A, et al. J Virol. 2014 Feb;88(3):1447-60.

2. Guan S, et al. Sci Rep. 2017 Jun 19;7(1):3786.

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