MBA-m1

Chemical Structure : MBA-m1

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货号: PC-24408Not For Human Use, Lab Use Only.

MBA-m1 is a specific small molecule inhibitor of mouse mixed lineage kinase domain-like (MLKL), targets the Hc/groove of mouse MLKL, delays necroptosis in mouse WT NIH-3T3 cells.

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生物&药学活性

MBA-m1 is a specific small molecule inhibitor of mouse mixed lineage kinase domain-like (MLKL), targets the Hc/groove of mouse MLKL, delays necroptosis in mouse WT NIH-3T3 cells.
MBA-m1 is as effective as Nec1s in mouse cells, acts by disrupting the Hc/groove interaction.
MBA-m1 inhibits necroptosis in Mlkl−/− NIH-3T3 cells re-expressing mMLKL2, does not affect RIPK3:MLKL interaction.
MBA-m1 ameliorates disease in mouse models of MLKL-driven dermatitis and abdominal aortic aneurysm.
MBA-m1 harbored significantly lower counts of CD68+ macrophages and Ly6G+ myeloid cells compared with those treated with vehicle in mice.

物理化学性质&存储条件

分子量	440.93
分子式	C27H21ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-chloro-4-(naphthalen-2-yloxy)phenyl)-6-methoxy-2-methylquinolin-4-amine

参考文献

1. Ros U, et al. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X.

MBA-m1

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物理化学性质&存储条件

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MBA-m1

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