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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Mixed Lineage Kinase (MLK)-MBA-h1
MBA-h1

Chemical Structure : MBA-h1

CAS No.: 899759-16-1

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MBA-h1

货号: PC-24409Not For Human Use, Lab Use Only.

MBA-h1 is a specific small molecule inhibitor of human mixed lineage kinase domain-like (MLKL), targets the Hc/groove of human MLKL, inhibits necroptosis in human WT HT-29 and HeLa-hRIPK3 knockin cells.

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5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MBA-h1 is a specific small molecule inhibitor of human mixed lineage kinase domain-like (MLKL), targets the Hc/groove of human MLKL, inhibits necroptosis in human WT HT-29 and HeLa-hRIPK3 knockin cells.
MBA-h1 inhibitsnecroptosis in MLKL−/− HT-29 cells re-expressing hMLKL1.

物理化学性质&存储条件

分子量 423.52
分子式 C26H25N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-(6-(4-methylpiperazin-1-yl)pyridazin-3-yl)phenyl)-2-naphthamide

参考文献

1. Ros U, et al. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X.

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