MASTL inhibitor MKI-2 | Greatwall inhibitor | Probechem Biochemicals

Chemical Structure : MASTL inhibitor MKI-2

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MASTL inhibitor MKI-2 (MASTL kinase inhibitor-2)

货号: PC-25466Not For Human Use, Lab Use Only.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MKI-2 (MASTL kinase inhibitor-2) is a potent small molecule inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall/GWL), inhibits recombinant MASTL activity and cellular MASTL activity with IC50 of 37.44 nM and 142.7 nM, respectively.
MKI-2 inhibits MASTL kinase rather than other AGC kinases, such as ROCK1, AKT1, PKACα, and p70S6K.
MKI-2 induces mitotic catastrophe of breast cancer cells via MASTL-PP2A regulation.
MKI-2 inhibits the oncogenic properties and enhances the radiosensitivity of breast cancer cells.
MKI-2 shows phenocopies with MASTL-null oocyte in mouse oocytes.

物理化学性质&存储条件

分子量	381.44
分子式	C22H19N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-((4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)amino)phenyl)acetonitrile

参考文献

1. Kang M, et al. Pharmaceuticals (Basel). 2021 Jul 5;14(7):647.

MASTL inhibitor MKI-2 (MASTL kinase inhibitor-2)

生物&药学活性

物理化学性质&存储条件

参考文献

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MASTL inhibitor MKI-2 (MASTL kinase inhibitor-2)

生物&药学活性

物理化学性质&存储条件

参考文献

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