MASP-2 inhibitor 22

Chemical Structure : MASP-2 inhibitor 22

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货号: PC-24087Not For Human Use, Lab Use Only.

MASP-2 inhibitor 22 is a potent, specific small-molecule inhibitor of mannan-binding lectin-associated serine proteases -2 (MASP-2) with IC50 of 8.9 nM, >40-fold selective over MASP-3.

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生物&药学活性

MASP-2 inhibitor 22 is a potent, specific small-molecule inhibitor of mannan-binding lectin-associated serine proteases -2 (MASP-2) with IC50 of 8.9 nM, >40-fold selective over MASP-3.

物理化学性质&存储条件

分子量	462.53
分子式	C23H22N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-amino-1H-imidazole-4-yl)benzyl)-2-(6-(phenylsulfonamido)pyridin-3-yl)acetamide

参考文献

1. Nakhla MC, et al. Eur J Med Chem. 2025 Jan 9;289:117238.