MA9-060 (MA9) | ULK3 inhibitor | Probechem Biochemicals

Chemical Structure : MA9-060

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MA9-060 (MA9060, MA9)

货号: PC-28344Not For Human Use, Lab Use Only.

MA9-060 (MA9) is a potent, seletive small molecule Unc-51 like kinase 3 (ULK3) inhibitor with IC50 of 226 nM, weakerly inhibits ULK1 (IC50=1046 nM).

规格	价格	库存	数量
25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

MA9-060 (MA9) is a potent, seletive small molecule Unc-51 like kinase 3 (ULK3) inhibitor with IC50 of 226 nM, weakerly inhibits ULK1 (IC50=1046 nM).
MA9-060 (MA9) is a type-1 inhibitor that engages the hinge Cys94 residue via hydrogen bonding to its pyrimidine N1 and 2-anilinyl NH groups.
MA9-060 (MA9) provokes rapid reductions in ULK3 levels and autophagy effectors in U266 MM cells, is not toxic to normal primary human MSCs. inhibit the proper formation of autophagolysosomes.
MA9-060 (MA9) significantly reduces MM growth and myeloma-associated bone disease in vivo, is sensitive for drug-resistant MM cells express increased levels of ULK3.
MA9-060 (MA9) displays potent anti-myeloma activity against patient derived MM cells ex vivo.

物理化学性质&存储条件

分子量	561.12
分子式	C27H34ClFN6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chloro-5-((2-((3-fluoro-4-(1-methylpiperidin-4-yl)phenyl)amino)-5-methylpyrimidin-4-yl)amino)phenyl)-2-methylpropane-2-sulfonamide

参考文献

1. Tauro M, et al. Nat Commun. 2026 Aug 25;17(1):10142.

2. Patent WO2022155593 A1 2022-07-21.

MA9-060 (MA9060, MA9)

生物&药学活性

物理化学性质&存储条件

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MA9-060 (MA9060, MA9)

生物&药学活性

物理化学性质&存储条件

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