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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aminopeptidase-M8891
M8891

Chemical Structure : M8891

CAS No.: 1464842-09-8

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M8891 (M 8891)

货号: PC-73107Not For Human Use, Lab Use Only.

M8891 (M 8891) is an orally bioavailable, potent, and reversible methionine aminopeptidase 2 (MetAP2) inhibitor with IC50 of 54 nM, Ki of 4.33 nM.

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2 mg ￥3280 In stock
5 mg ￥4980 In stock
10 mg ￥7880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

M8891 (M 8891) is an orally bioavailable, potent, and reversible methionine aminopeptidase 2 (MetAP2) inhibitor with IC50 of 54 nM, Ki of 4.33 nM.
M8891 impede the growth of primary endothelial cells and demonstrated antitumoral activity in mouse models.

物理化学性质&存储条件

分子量 385.37
分子式 C20H17F2N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-3-Hydroxy-1-(1H-indol-5-yl)-2-oxo-pyrrolidine-3-carboxylic Acid 3,5-Difluoro-benzylamide

参考文献

1. Heinrich T, et al. J Med Chem. 2019 Dec 26;62(24):11119-11134.

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