M6766 | ERO1α inhibitor | Probechem Biochemicals

Chemical Structure : M6766

加入收藏

M6766 (M-6766)

货号: PC-25115Not For Human Use, Lab Use Only.

M6766 is a potent, selective inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α) with IC50 of 1.4 uM and KD of 1.1 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

M6766 is a potent, selective inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α) with IC50 of 1.4 uM and KD of 1.1 uM.
M6766 exhibits >70-fold selectivity over other tested enzymes, except ERO1β (IC50=7.2 μM).
M6766 binds to the FAD-binding pocket in ERO1α.
M6766 concentration-dependently inhibits granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation induced by various agonists, but it does not affect agonist-induced production of reactive oxygen species.
M6766 diminishes platelet accumulation on collagen-coated surfaces under arterial shear conditions.
M6766 decreases arterial thrombosis and infarct volume during ischemic stroke without prolonging tail bleeding times in mice.

物理化学性质&存储条件

分子量	360.44
分子式	C19H16N6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	11-((4-methyl-4H-1,2,4-triazol-3-yl)thio)-7,8,9,10-tetrahydrobenzo[4,5]imidazo[1,2-b]isoquinoline-6-carbonitrile

参考文献

1. Wang J, et al. Mol Ther. 2025 Jul 23:S1525-0016(25)00569-6.

M6766 (M-6766)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

M6766 (M-6766)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.