M606 | MYCN inhibitor, Iron chelator | Probechem Biochemicals

Chemical Structure : M606

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M606 (MYCN/c-Myc inhibitor)

货号: PC-24710Not For Human Use, Lab Use Only.

M606 is a selective, iron-chelating small molecule inhibitor of MYCN/c-Myc, reduces MYCN protein expression by acting on the MYCN promoter via E2F3-mediated transcription factor binding sites.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

M606 is a selective, iron-chelating small molecule inhibitor of MYCN/c-Myc, reduces MYCN protein expression by acting on the MYCN promoter via E2F3-mediated transcription factor binding sites.
M606 reduced MYCN mRNA levels in the MYCN-amplified human neuroblastoma cell line BE(2)-C in a time-dependent manner.
M606 reduced MYCN protein levels in BE(2)-C cells and c-MYC protein levels in the human hepatoblastoma cell line, HepG2, in a dose- and time-dependent manner.
M606 (2.5-25 uM) inhibits cell proliferation in MYC-expressing cell line SHR6-17.
M606 (1-5 uM) reduces clonogenic capacity in clonogenic assays on MYCN-amplified BE(2)-C and LAN-1 neuroblastoma cells.
M606 is cytotoxic in a panel of MYCN expressing (BE(2)-C, KELLY, IMR-32, LAN-1, NBL-WN) and c-MYC expressing (NBL-S, SY-5Y, SH-EP) neuroblastoma cell lines, but less cytotoxic to the nonmalignant fibroblast cell lines MRC5 and HSF.
M606 (25 mg/kg) inhibits tumor formation in the TH-MYCN transgenic mouse model of neuroblastoma.
M606 decreases MYC-mediated transcription in HepG2 cells but also a dramatic dose-dependent increase in HIF1A.
M606 is an iron chelator that modulates glucose metabolism, inhibits TCA cycle activity in neuroblastoma cells.
M606 mediates downregulation of MYCN via transcription factor E2F3, acts on the MYCN promoter via E2F3-mediated binding sites to reduce MYCN protein expression.

物理化学性质&存储条件

分子量	300.40
分子式	C18H24N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(methoxymethyl)-7-((4-methylpiperidin-1-yl)methyl)quinolin-8-ol

参考文献

1. Pandher R, et al. Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2420011122.

M606 (MYCN/c-Myc inhibitor)

生物&药学活性

物理化学性质&存储条件

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M606 (MYCN/c-Myc inhibitor)

生物&药学活性

物理化学性质&存储条件

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