M511-0965

Chemical Structure : M511-0965

加入收藏

货号: PC-27157Not For Human Use, Lab Use Only.

M511-0965 is a small-molecule inhibitor of YAP-TEAD4, binds directly to TEAD4 with MST Kd of 2.76 uM, shows growth inhibition in MDA-MB-231 cells with IC50 of 1.135 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

M511-0965 is a small-molecule inhibitor of YAP-TEAD4, binds directly to TEAD4 with MST Kd of 2.76 uM, shows growth inhibition in MDA-MB-231 cells with IC50 of 1.135 uM.
M511-0965 (0.5 µM, 1 µM, 2 µM) impairs the biological functions of TNBC by restricting the binding of YAP-TEAD4.
TGFB2 serves as a downstream target of M511-0965 inhibiting TNBC progression.
M511-0965 inhibits the expression of TGFB2 by suppressing the binding of YAP-TEAD4, thereby inhibiting the proliferation, invasion and migration of TNBC cells and promoting cell apoptosis.

物理化学性质&存储条件

分子量	335.45
分子式	C21H25N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1-isobutyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethyl)-2-methylbenzamide

参考文献

1. Cheng M, et al. Transl Oncol. 2026 Jun 28;71:102881.

M511-0965

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

M511-0965

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.