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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Urea Transporter-M353-0039
M353-0039

Chemical Structure : M353-0039

CAS No.: 1185074-29-6

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M353-0039 (M 353-0039)

货号: PC-26596Not For Human Use, Lab Use Only.

M353-0039 is a highly potent and selective inhibitor of urea transporter UT-A2 with IC50 of 0.35 uM, shows no detective activity against UT-A3 or UT-B.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    M353-0039 is a highly potent and selective inhibitor of urea transporter UT-A2 with IC50 of 0.35 uM, shows no detective activity against UT-A3 or UT-B.
    M353-0039 exhibited no significant inhibition of UT-A1-mediated urea transport.
    M353-0039 exerts selective inhibitory effects on UT-A2 within the mouse kidney medulla.
    M353-0039 effectively blocks urea transport in HepG2 cells.

    物理化学性质&存储条件

    分子量 361.43
    分子式 C16H15N3O3S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-((2-methyl-5-(4-methylthiazol-2-yl)thiophen-3-yl)amino)-2-oxoethyl)furan-2-carboxamide

    参考文献

    1. Liu L, et al. Nat Commun. 2026 Apr 20. doi: 10.1038/s41467-026-71834-w.

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