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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-M2I-1
M2I-1

Chemical Structure : M2I-1

CAS No.: 312271-03-7

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M2I-1 (Mad2 inhibitor 1)

货号: PC-42103Not For Human Use, Lab Use Only.

M2I-1 is the first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20.

规格 价格 库存 数量
10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

M2I-1 is the first small molecule Mad2 inhibitor that targets the binding of Mad2 to Cdc20.
M2I-1 is equally potent in inhibiting the binding of F-Mbp1 to Mad2.
M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20, weakens the spindle assembly checkpoint (SAC) response.

物理化学性质&存储条件

分子量 404.4832
分子式 C19H24N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
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Solubility

DMSO: ≥ 32 mg/mL
Chemical Name/SMILES

4,6(1H,5H)-Pyrimidinedione, 5-[[4-[bis(2-methylpropyl)amino]-3-nitrophenyl]methylene]dihydro-2-thioxo-

参考文献

1. Kastl J, et al. ACS Chem Biol. 2015 Jul 17;10(7):1661-6.

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